Amitriptyline: Details about the Medication

Amitriptyline: Details about the Medication

What is Amitriptyline?

Amitriptyline, also known by its brand name Elavil, is a tricyclic antidepressant prescribed by doctors to treat various mental illnesses such as major depressive disorder, anxiety disorder, attention deficit hyperactivity disorder, and bipolar disorder. It is also effective in relieving migraine pain, neuropathic pain, fibromyalgia, and postherpetic neuralgia. Amitriptyline works by affecting the central nervous system (CNS) and releasing certain chemicals in the brain. This medication is available in oral form and can only be obtained with a valid prescription from a doctor.

Important Information

  • Regularly visit your doctor and undergo frequent check-ups while taking Amitriptyline.
  • If you require surgery while on this medication, inform your doctor in advance about your use of Amitriptyline.
  • Consult your doctor before discontinuing this medication to avoid unpleasant withdrawal symptoms.
  • Amitriptyline may affect your blood sugar levels, so notify your doctor if you notice any significant changes.

What to Know Before Taking Amitriptyline?

Avoid taking Amitriptyline if you are allergic to it or any of its components, or if you have:

  • Recently had a heart attack
  • Taken an MAO inhibitor such as methylene blue injection within the last 14 days
  • Taken an SSRI antidepressant within the last five weeks

Prior to taking Amitriptyline, inform your doctor if you have or have had any of the following medical conditions:

  • Bipolar disorder
  • Mental illness or psychosis
  • Liver disease
  • Heart disease
  • Heart attack or stroke
  • Seizures
  • Diabetes
  • Glaucoma
  • Urination problems

Lactating mothers and pregnant women should consult their doctor before taking this medication.

How to Take Amitriptyline?

Take Amitriptyline exactly as prescribed by your doctor. Follow all the instructions on the prescription label and medication guide carefully. Do not exceed the recommended dosage and maintain consistency throughout the treatment. If you do not experience any improvement in your condition, consult your doctor. Keep the medication out of reach of children and store it at room temperature away from heat and moisture. After completing the treatment, consult your pharmacist for proper disposal of any leftover medication.

Amitriptyline Dosage

The dosage of Amitriptyline prescribed by your doctor depends on several factors, including:

  • Your age and weight
  • Your symptoms
  • The severity of your condition
  • Other medical conditions you may have
  • Other medications you are taking
  • Your initial response to the medication

The doctor may adjust the dosage of Amitriptyline based on different medical conditions.

Dosage for Depression

Oral tablets:

  • For older adults (65 years and above):

10 mg three times a day and 20 mg at night before bedtime. Your doctor may adjust your dose if necessary.

  • For adults (between 18 years and 65 years):

75 mg of Amitriptyline tablets per day, taken once or twice a day. Alternatively, your doctor may suggest taking 50 mg to 100 mg once a day at night before bedtime. However, the maximum daily dose should not exceed 150 mg under normal circumstances.

  • For children (between 12 years and 18 years):

10 mg three times a day and 20 mg at night before bedtime. Your doctor may adjust the dose if necessary.

  • For children (under 12 years of age):

The dosage of Amitriptyline for this age group should be determined by a doctor after a thorough examination.


If you feel unwell after taking Amitriptyline or have taken an excessive amount of the medication, consult your doctor and seek immediate medical assistance. You can contact the poison helpline at 1-800-222

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